Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Targeted Next-Generation Sequencing in MDS
Am J Hematol; ePub 2017 Sep 5; Tefferi, et al
Targeted next-generation sequencing (NGS) could help clinicians make decisions about treating patients with lower risk myelodysplastic syndrome (MDS), according to a study involving 179 individuals. Investigators used a 27-gene panel for NGS in participants with primary MDS. Among the results:
- At least 1 mutation/variant was seen in 82% of patients.
- Nearly one-fourth had ≥3 mutations/variants.
- 83% of patients died and 15% experienced leukemic transformations over a median follow-up of 30 months.
- ASXL1, SETBP1, and TP53 were found to be risk factors for overall survival, and SRSF2, IDH2, and CSF3R were identified as such for leukemia-free survival.
- 4 in every 10 patients had at least 1 adverse mutation/variant for overall survival.
- 2 in every 10 had at least 1 such mutation/variant for leukemia-free survival.
- The number of mutations/variants did not improve prognostic value.
- Survival impact of adverse mutations was most evident in IPSS-R very low/low risk patients.
Citation:
Tefferi A, Lasho T, Patnaik M, et al. Targeted next-generation sequencing in myelodysplastic syndromes and prognostic interaction between mutations and IPSS-R. [Published online ahead of print September 5, 2017]. Am J Hematol. doi:10.1002/ajh.24901.
