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Consider This Method to Measure JAK2 Status in MF

Leuk Res; 2017 Dec; Strati, Benton, et al

Publish date:

Saliva testing is an easier and possibly more reliable method than peripheral blood for measuring JAK2 status and assessing V617F allelic burden in transfusion-dependent patients with myelofibrosis (MF), according to a prospective study involving 167 individuals. Investigators used both methods simultaneously on participants who had MF. Among the results:

  • Concordance between the 2 methods was 96%.
  • Sensitivity and specificity were 100% and 90%, respectively.
  • Ongoing transfusion dependency was the only factor linked with false positive results from saliva testing.

Citation:

Strati P, Benton CB, Manshouri T, et al. JAK2V617F detection and allele burden measurement in saliva vs peripheral blood in patients with myelofibrosis. Leuk Res. 2017;63:53-55. doi:10.1016/j.leukres.2017. 10.016.

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