Fluid overload grade ≥2 is linked with higher non-relapse mortality and shorter survival, according to a study involving 2 cohorts of nearly 600 individuals. One group underwent haploidentical transplantation for hematologic malignancies following a melphalan-based conditioning regimen (n=145). Investigators evaluated the impact fluid overload had on transplant outcomes. They also looked at a validation cohort of patients with acute myeloid leukemia/myelodysplastic syndrome who underwent HLA-matched transplant (n=449) with busulfan-based conditioning. Among the results:

• In univariate analysis, patients with fluid overload grade ≥2 were 15 times more likely to experience non-relapse mortality by day 100.
• Patients with creatinine >1 mg/dL and those >55 years of age were both nearly 5 times more likely to experience such.
• In multivariate analysis, patients with fluid overload grade ≥2 were 13 times more likely to experience non-relapse mortality by day 100.
• Patients with creatinine >1 mg/dL were nearly 4 times more likely to experience such.
• Findings were verified in the validation cohort.