Neoadjuvant Therapy With Docetaxel and Ketoconazole in Patients With High-Risk Prostate Cancer: A Pilot Study (IST 16167)
Eligible patients with high-risk prostate cancer who are scheduled to undergo radical prostatectomy will receive 4 cycles of therapy with ketoconazole and docetaxel prior to surgery resection. A cycle of therapy is defined as 21 days (3 weeks). Pharmacokinetic analysis will be performed during the first and second cycles of therapy. All patients will be evaluated for toxicity, tumor response, and recurrence.
ID: NCT00870714
Sponsor, Collaborator: Kansas City VAMC; Sanofi
Location: Kansas City VAMC
A Study of Epirubicin With Estramustine Phosphate and Celecoxib for the Treatment of Prostate Cancer
The purpose of this clinical trial is to find out the effect of epirubicin with estramustine phosphate and celecoxib on PSA and objective response in patients with hormone-resistant prostate cancer, as well as to evaluate the toxicity and quality of life of this combination. Celecoxib is an FDA-approved drug that treats arthritis. Epirubicin, alone or with estramustine phosphate, has been used in the treatment of hormone-resistant prostate cancer. These drugs have demonstrated evidence of tumor blood vessel suppression and a combination of these 3 drugs could possibly arrest further tumor growth or even make the tumor decrease in size.
ID: NCT00218205
Sponsor, Collaborator; Investigator: VA New Jersey Health Care System; Pfizer; Basil Kasimis, MD
Location: VA New Jersey Health Care System
A Phase II Trial of Combination Therapy With Celecoxib and Taxotere for the Treatment of Stage D3 Prostate Cancer
The purpose of this clinical trial is to find out the safety and effectiveness as well as the patient’s quality of life while taking the combination of Taxotere and celecoxib on patients with hormone refractory prostate cancer. Celecoxib (Celebrex) is an FDA-approved drug that treats arthritis. Taxotere (Docetaxel) is an FDA-approved chemotherapy drug to treat certain forms of cancer. Both drugs have demonstrated evidences of tumor blood vessel suppression and combination of these 2 drugs could possibly arrest further tumor growth or make the tumor decrease in size.
ID: NCT00215345
Sponsor, Collaborator; Investigator: Department of Veterans Affairs, New Jersey; Pfizer, Sanofi; Basil Kasimis, MD
Location: VA New Jersey Health Care System
A Yoga Program for Patients Undergoing Prostate Cancer Surgery
Men with localized prostate cancer are often treated with surgery, a treatment that is associated with high rates of adverse effects such as erectile dysfunction (ED) and urinary incontinence (UI) which impact quality of life. Yoga may improve control of UI and improve ED by bringing awareness to and strengthening the pelvic floor musculature. The randomized controlled pilot study is to assess the feasibility of an innovative hybrid (in-person and virtual) twice-weekly yoga program that includes a prehabilitation component and to obtain preliminary data that will help assess its potential effectiveness in alleviating prostate cancer treatment symptom burden (primarily ED and UI). The long-term goal is to develop a scalable and sustainable yoga program that helps cancer survivors manage their treatment side effects.
ID: NCT05929300
Sponsor, Investigator: VA Office of Research and Development; Abigail Silva, PhD, MPH
Location: Edward Hines Jr. VA Hospital
