Enzalutamide With or Without Abiraterone and Prednisone in Treating Patients With Castration-Resistant Metastatic Prostate Cancer
This randomized phase III trial studies enzalutamide to see how well it works compared to enzalutamide, abiraterone, and prednisone in treating patients with castration-resistant metastatic prostate cancer. Androgens can cause the growth of prostate cancer cells. Drugs, such as enzalutamide, abiraterone acetate, and prednisone, may lessen the amount of androgens made by the body.
ID: NCT01949337
Sponsor; Collaborators: Alliance for Clinical Trials in Oncology; NCI, Astellas Pharma US, Inc., Medivation, Inc., Biologics, Inc.
Locations: 539 locations, including VA Connecticut Healthcare System
S1216, Phase III ADT+TAK-700 vs ADT+Bicalutamide for Metastatic Prostate Cancer (S1216)
The purpose of this study is to compare overall survival in newly diagnosed metastatic prostate cancer patients randomly assigned to ADT + TAK-700 vs androgen deprivation therapy (ADT) + bicalutamide.
ID: NCT01809691
Sponsor; Collaborators: SWOG Cancer Research Network; Millennium Pharmaceuticals, Inc., NCI
Locations: 560 locations, including VA New York Harbor Healthcare System
Androgen Ablation Therapy With or Without Chemotherapy in Treating Patients With Metastatic Prostate Cancer (CHAARTED)
RATIONALE: Androgens can cause the growth of prostate cancer cells. Androgen ablation therapy may stop the adrenal glands from making androgens. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether androgen-ablation therapy is more effective with or without docetaxel in treating metastatic prostate cancer.
PURPOSE: This randomized phase III trial is studying androgen ablation therapy and chemotherapy to see how well they work compared to androgen ablation therapy alone in treating patients with metastatic prostate cancer.
ID: NCT00309985
Sponsor; Collaborator: ECOG-ACRIN Cancer Research Group; NCI
Locations: 343 locations, including Mather VAMC
