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Hormonal Contraception & Thromboembolism Risk
Diabetes Care; ePub 2016 Nov 29; O”Brien, et al
For women with type 1 or 2 diabetes using hormonal contraception, the absolute risk of thromboembolism is low, a recent study found. The study used data from 2002-2011 in Clinformatics Data Mart to identify US women aged 14 to 44 years with diabetes and a prescription for a diabetic medication or device. Researchers found:
- 146,080 women with diabetes who experienced 3,012 thromboembolic events were identified.
- Only 28% of reproductive-aged women with diabetes had any claims for hormonal contraception, with the majority receiving estrogen-containing oral contraceptives.
- Rates of thromboembolism were highest among women who used the contraceptive patch (16 per 1,000 woman-years), and lowest among women who used intrauterine (6 per 1,000 women-years) and subdermal (0 per 163 women-years) contraceptives.
- Progestin-only injectable contraception was associated with increased risk of thromboembolism (12.5 per 1,000 women-years; aHR, 4.69), compared with use of intrauterine.
Citation:
O’Brien SH, Koch T, Vesely SK, Schwarz EB. Hormonal contraception and risk of thromboembolism in women with diabetes. [Published online ahead of print November 29, 2016]. Diabetes Care. doi:10.2337/dc16-1534.