Diabetic ketoacidosis occurs frequently in infants with diabetes, underscoring the need to educate pediatric providers about the ways such patients can present with the condition, according to a study involving 88 individuals. Subjects were diagnosed with diabetes at a median of 10.4 weeks. Investigators looked at lab values, signs, and symptoms. If a causal mutation for diabetes was detected, subjects were subdivided by similar mutation subtypes. Among the results:

• 33 patients had KCNJ11- related diabetes.
• 19 had an unknown subtype, likely type 1 diabetes.
• 12 had transient neonatal diabetes.
• Diagnosis age was substantially lower in the transient group (median .043 weeks, vs 15.2 weeks in those with permanent diabetes).
• The most common signs/symptoms were polyuria (n=32), tachypnea (n=31), flu-like symptoms (n=30), tiredness/weakness (n=28), dehydration (n=27), and “not acting right” (n=26).
• Overall frequency of DKA was 66%, and the odds of experiencing it increased with age.