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BP Levels and Risk of Adverse Renal Events in T1D
Diabetes Care; ePub 2016 Nov 21; Ku, et al
Patients with type 1 diabetes who have a lower blood pressure (BP) of <120/70 mmHg had a substantially lower risk of adverse renal outcomes, regardless of the prior assigned glycemic control strategy, a recent study found. Researchers studied 1,441 participants with type 1 diabetes aged 13 to 39 years who had previously been randomized to receive intensive vs conventional glycemic control in the Diabetes Control and Complications Trial (DCCT). They found:
- There were 84 cases of stage III chronic kidney disease (CKD) and 169 cases of macroalbuminuria during median follow-up of 24 years.
- Systolic BP (SBP) in the <120 mmHg ranges was associated with a 0.59 times risk of macroalbuminuria and a 0.32 times risk of stage III CKD compared with SBPs between 130 and 140 mmHg.
- Diastolic BP (DBP) in the <70 mmHg ranges were associated with a 0.73 times risk of macroalbuminuria and a 0.47 times risk of stage III CKD compared to DBPs between 80 and 90 mmHg.
Ku E, McCulloch CE, Mauer M, Gitelman SE, Grimes BA, Hsu C. Association between blood pressure and adverse renal events in type 1 diabetes. [Published online ahead of print November 21, 2016]. Diabetes Care. doi:10.2337/dc16-0857.