Cardiology
Q&A
Antioxidants do not prevent heart disease in high-risk individuals
MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomized placebo-controlled trial....
Q&A
β-Blocker survival benefit outweighs side-effect risks
Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. β-Blocker therapy and symptoms of depression, fatigue and sexual dysfunction....
Q&A
B-type natriuretic peptide is an accurate predictor of heart failure in the emergency department
Maisel AS, Krishnaswamy P, Nowak RM, et al. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J...
Commentary
Electronic solutions to implementing lipid guidelines
Clinical Inquiries
When should patients with asymptomatic aortic stenosis be evaluated for valve replacement?
EVIDENCE-BASED ANSWER: For patients whose echocardiograms show advanced calcification of the aortic valves, a jet velocity of > 4.0 m/s, or a...
Original Research
Stage-matched nutrition guidance for patients at elevated risk for cardiovascular disease: A randomized intervention study in family practice
Q&A
Cost effectiveness of aspirin vs clopidogrel for secondary prevention of coronary heart disease
Gaspoz JM, Coxson PG, Goldman PA, et al. Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease. N...
Original Research
Aspirin prophylaxis in patients at low risk for cardiovascular disease: A systematic review of all-cause mortality
OBJECTIVE: We investigated whether aspirin reduces all-cause mortality in low-risk patients.STUDY DESIGN: We systematically reviewed studies of...
Clinical Inquiries
Does a low-salt diet reduce morbidity and mortality in congestive heart failure?
EVIDENCE-BASED ANSWER: No randomized controlled trials (RCTs) have addressed the independent role of sodium restriction in the morbidity or...
Q&A
ACE inhibitors prevent stroke in high-risk patients, independent of blood pressure-lowering effect
Bosch J, Yusuf S, Pogue J, et al. Use of ramipril in preventing stroke: double blinded randomized trial. BMJ 2002; 324:699–702.
Q&A
Utility of Factor V Leiden testing for idiopathic venous thromboembolism is unclear
Eckman MH, Singh SK, Erban JK, Kao G. Testing for Factor V Leiden in patients with pulmonary or venous thromboembolism: a cost-effective analysis...