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Childhood BMI-Adult Diabetes Link Evaluated
Diabetes Care; ePub 2018 Feb 26; Geng, et al
A genetic predisposition to childhood BMI was linked with increased risk of type 2 diabetes and coronary artery disease (CAD) in adulthood, according to a recent analysis. Investigators used 15 single nucleotide polymorphisms (SNPs) to test the causal effect of childhood BMI on cardiometabolic diseases. A 1-standard deviation (SD) increase in childhood BMI was linked with an:
- 83% increase in risk of type 2 diabetes.
- 28% increase in risk of CAD.
- 0.587 kg/m2-SD increase in adult BMI.
- 0.062-cm SD increase in hip circumference.
- 0.602-cm-SD increase in waist circumference.
- 0.111 pmol/L increase in log fasting insulin.
- 0.068 increase in log HOMA β.
- 0.126 increase in log HOMA of insulin resistance.
- 0.109-mg/dL SD increase in triglyceride.
- 0.138-mg/dL-SD decrease in HDL.
Citation:
Geng T, Smith C, Li C, Huang T. Childhood BMI and adult type 2 diabetes, coronary artery diseases, chronic kidney disease, and cardiometabolic traits: A Mendelian randomization analysis. [Published online ahead of print February 26, 2018]. Diabetes Care. doi:10.2337/dc17-2141.