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These Diabetes Patients Have Increased CV Risks
Diabetes Care; ePub 2017 Jan 25; Lee, et al
American Indian diabetes patients who have both high triglycerides and low HDL-C are at increased risk of coronary heart disease (CHD) and stroke, according to a prospective cohort study involving more than 3,200 individuals.
Participants were American Indian, and did not have CV disease at baseline; 41% had diabetes. Investigators looked at stroke and CHD incidence relative to triglyceride and HDL-C status. They performed analyses by age, sex, BMI, smoking, diabetes, fasting LDL-C level, antihypertensive medications, physical activity, estimated glomerular filtration rate, and urinary albumin-to-creatinine ratio. Among the results:
- Patients with high triglycerides and low HDL levels had a 32% higher risk of CHD than those with normal levels.
- Diabetes patients with high triglycerides and low HDL levels had a 54% higher risk of CHD, and a more than 2-fold risk of stroke.
- Gender did not impact these associations.
Lee J, Chang P, Zhang Y, Kizer J, Best L, Howard B. Triglyceride and HDL-C Dyslipidemia and Risks of Coronary Heart Disease and Ischemic Stroke by Glycemic Dysregulation Status: The Strong Heart Study. [Published online ahead of print January 25, 2017]. Diabetes Care. doi:10.2337/dc16-1958.