Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Severe Hypoglycemia Risk in T2D After CV Event
Diabetes Care; ePub 2018, Jan 8; Strandl, et al
People with type 2 diabetes are more apt to experience severe hypoglycemia after a cardiovascular (CV) event, and vice versa, according to a study involving nearly 14,700 individuals. Participants from the TECOS study had type 2 diabetes and CV disease. Investigators followed them for a median of 3 years, looking at the link between severe hypoglycemia and a CV composite of fatal/nonfatal myocardial infarction (MI) or stroke, hospitalization for unstable angina, or hospitalization for heart failure.
After adjusting for certain variables, patients with severe hypoglycemic events were:
- 55% more likely to experience the CV composite.
- 83% more likely to experience all-cause death.
- 72% more likely to experience CV death.
Additionally, a higher risk of severe hypoglycemic events was seen in patient with:
- Nonfatal MI: >3 times higher.
- Nonfatal stroke: nearly 3 times higher.
- Heart failure: nearly 4 times higher.
Strandl E, Stevens S, Armstrong P, et al. Increased risk of severe hypoglycemic events before and after cardiovascular outcomes in TECOS suggests an at-risk type 2 diabetes frail patient phenotype. [Published online ahead of print January 8, 2017]. Diabetes Care. doi:10.2337/dc17-1778.