Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Predicts MI, CV Death in People with Diabetes

Diabetes Care; 2018 Jan 30; Hunt, Jaffa, et al

Publish date:: February 2, 2018

High levels of connective tissue growth factor (CTGF) appear to predict myocardial infarction (MI) and cardiovascular (CV) death in people with type 2 diabetes, according to a study involving 952 individuals. Participants were from the Veterans Affairs Diabetes Trial. Investigators measured CTGF a median of ~2 years after the study began, and followed patients for an average of ~3 years, looking at vascular outcomes. Among the results:

5% had an MI.
7% had an MI- or CV-related death.
After adjusting for certain variables, patients with higher levels of CTGF had a >2-fold elevated risk of MI, vs those with undetectable levels.
They had a nearly 3-fold higher risk of both MI/CV death and all-cause mortality.

Citation:

Hunt K, Jaffa M, Garrett S, et al. Plasma connective tissue growth factor (CTGF/CCN2) levels predict myocardial infarction in the Veterans Affairs Diabetes Trial (VADT) cohort. [Published online ahead of print January 30, 2018]. Diabetes Care. doi:10.2337/dc17-2083.

This Week's Must Reads

Higher dose maximizes effects of magnesium sulfate for obese women,

Microplastics permeate human placentas,

One in five gestational carriers do not meet ASRM criteria,

Gender surgical outcomes differ following puberty suppression,

COVID-19 vaccine found effective but doctors watching for reactions, adverse events,

Must Reads in Diabetes

Sac/val heart failure benefit extends to diabetes patients,

Don’t miss cardiovascular risk factors in transgender patients,

Semaglutide shows promise in NASH phase 2 study,

‘Modest’ benefit for post-MI T2D glucose monitoring,

Diabetic neuropathic pain linked to brain bioenergic anomalies,