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Clinical Features of High Risk Melanoma Examined

JAMA Dermatol; ePub 2016 Nov 9; Watts, Madronio, et al

A person’s risk factor status for melanoma could be used to tailor surveillance programs and education about skin self-examination, a recent study found. Researchers conducted a population-based observational study of physicians’ reported treatment of 2,727 patients diagnosed with an in situ or invasive primary melanoma over a 12-month period; analysis of these data took place from 2015 to 2016. They found:

  • Of total patients with melanoma, 1,052 (39%) were defined as higher risk owing to a family history of melanoma, multiple primary melanomas, or many nevi.
  • Compared with patients with melanoma who were at lower risk, the higher-risk group had a younger mean age at diagnosis (62 vs 65 years), but this differed by risk factor.
  • Among higher-risk patients, those with many nevi were more likely to have melanoma on the trunk, those with a family history of melanoma were more likely to have melanomas on the limbs, and those with a personal history were more likely to have melanoma on the head and neck.

Citation:

Watts CG, Madronio C, Morton RL, et al. Clinical features associated with individuals at higher risk of melanoma. A population-based study. [Published online ahead of print November 9, 2016]. JAMA Dermatol. doi:10.1001/jamadermatol.2016.3327.