There is an increased risk of squamous cell carcinoma (SCC) development in the setting of atopic dermatitis (AD), according to a recent study. Researchers conducted a retrospective, case–control study of patients residing in Olmsted County, MN. Cases were selected from patients seen at Mayo Clinic who had an initial SCC diagnosis (either invasive SCC or SCC in situ) from January 1, 1996, through December 23, 2010. Age- and sex-matched controls were selected from patients seen at Mayo Clinic with no history of SCC before the case event date. 399 individuals with a documented history of SCC were identified and matched with 780 controls who did not have a history of SCC. Researchers found that after adjusting for race, smoking history, ionizing radiation exposure, corticosteroid and cyclosporine use, and non-SCC skin cancers, the odds ratio for SCC development between patients with history of AD vs patients without history of AD was 1.75.