Patients with comorbid fibromyalgia and migraine reported more depressive symptoms, higher headache intensity, and were more likely to have severe headache related disability compared to those with migraine only, a recent study found. Cases of comorbid fibromyalgia and migraine were identified using a prospectively maintained headache database at Mayo Clinic Rochester. Depressive symptoms as assessed by PHQ-9, intensity of headache, and migraine related disability as assessed by Migraine Disability Assessment Score (MIDAS) were primary measures used to compare migraine patients with comorbid fibromyalgia vs those without. Researchers found:

• 157 cases and 471 controls were identified for the study.

• Patients with comorbid fibromyalgia reported significantly higher PHQ-9 scores (OR 1.08) and headache intensity score (OR 1.149).
• There was no significant difference in migraine related disability (OR 1.002).
• Patients with fibromyalgia were more likely to score in a higher category of depressive severity (OR 1.467) and more likely to score in a higher category of migraine related disability (OR 1.23).