Fecal blood test (FBT) outreach and patient navigation were associated with increased colorectal cancer (CRC) screening rates in the US, a recent study found. The systematic review and meta-analysis included 73 randomized clinical trials (n = 366,766 patients) of US-based interventions in clinical settings designed to improve CRC screening test completion in average-risk adults. The primary outcome was completion of CRC screening. Among the findings:

• Interventions that were associated with increased CRC screening completion rates compared with usual care included FBT outreach, patient navigation, patient education, patient reminders, clinician interventions of academic detailing, and clinician reminders.
• Combinations of interventions were associated with greater increased than single components.
• Repeated mailed FBTs with navigation were associated with increased annual FBT completion.