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Endogenous retroviruses may unlock new immunotherapy targets
Future epigenetic drugs could activate human endogenous retroviruses (HERVs) in cancer cells to enable immunotherapy, investigators suggest.
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Dramatic response from pembrolizumab in patient with Lynch syndrome
A woman with two distinct primary tumors caused by Lynch syndrome achieved complete regression of both after pembrolizumab therapy.
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Brentuximab vedotin boosts elderly Hodgkin survival
Adding Bv to standard chemotherapy improved survival over historical rates.
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First combo trial of mTOR/BRAF inhibition shows potential
A combination of the mammalian target of rapamycin (mTOR) inhibitor everolimus and the BRAF inhibitor vemurafenib appears safe for patients with...
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Ulipristal reduces bleeding with contraceptive implant
Dr. Eve Espey says toxicity concerns must be addressed before a clinical roll out.
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Guideline-recommended tests’ prognostic ability affirmed in prostanoid-treated PAH
Test results sorted patients into lower, intermediate, or higher risk for mortality.
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Guideline offers comprehensive approach for ICU clinicians
The guideline is comprehensive, consisting of both broad and specific descriptions of current ICU practices and associated evidence.
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PARP inhibitor plus trabectedin shows promise for sarcoma
Investigators planning phase 2 studies after phase 1b results demonstrated tolerability and efficacy with the combination of olaparib and...
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Kymriah cost effectiveness depends on long-term outcomes
The value proposition for the pricey CAR T-cell therapy depends on whether the real-world outcomes are as good as the ones seen in clinical trials...
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Updated IPF guideline refines diagnostic criteria with HRCT
Use of serum biomarkers to distinguish IPF from other lung diseases wasn’t recommended.
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SBRT controls oligometastatic RCC in majority of patients
Stereotactic body radiation therapy (SBRT) is a safe and effective treatment option for patients with oligometastatic renal cell carcinoma (RCC),...
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Repeat MRI not useful in suspected axial spondyloarthritis
Male gender and HLA-B27 positivity were found to be important predictors of a positive MRI.
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Outpatient costs soar for Medicare patients with chronic hepatitis B
Inpatient costs also increased, but less dramatically.
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HIV-associated Kaposi sarcoma responds to checkpoint inhibitors
Checkpoint inhibitor therapy is effective for patients with HIV-associated Kaposi sarcoma (KS), a recent study has found.
Partial or...