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How nonadherence complicates cardiology, in two trials
Nonadherence prevents patients from achieving treatment benefits, but it also complicates trial interpretation, suggests subanalyses of MASTER...
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Concerns that low LDL-C alters cognitive function challenged in novel analysis
A Mendelian randomization study appears to exonerate very low LDL-C but not therapies from altering cognition.
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COVID skin manifestations vary by type of variant, U.K. study finds
Omicron and Delta COVID-19 skin manifestations differ, according to large U.K. patient survey.
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Remnant cholesterol captures residual CV risk in patients with T2D
Baseline and follow-up remnant cholesterol levels predict cardiovascular events in patients with type 2 diabetes.
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Questionnaire for patients with psoriasis might identify risk of axial involvement
A patient-completed questionnaire shows promise for detecting risk of undiagnosed axial involvement in psoriasis.
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NAFLD strongly correlated with psoriasis, PsA; risk linked to severity
The risk of nonalcoholic fatty liver disease is doubled by psoriasis, and severity is a related variable.
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Neural networks can distinguish PsA from rheumatoid arthritis on MRI
Deep-learning programming can be trained to distinguish inflammatory joint diseases with reasonable accuracy.
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New algorithm for initial PsA treatment choice is driven by
T-cell behavior
A novel treatment algorithm for psoriatic arthritis (PsA) is being developed to provide more precise biologic choices.
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Transgender youth on hormone therapy risk substantial bone loss
“We need more information on the optimal length of treatment with puberty-delaying medications before either discontinuation or introduction of...
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Mobile devices ‘addictive by design’: Obesity is one of many health effects
Patients need help with compulsive use of wireless devices, which leads to weight gain and other health risks.
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Bone density loss in lean male runners parallels similar issue in women
Male runners with lean body mass, like female runners, risk bone density loss that may be hormonally related.
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Nonhormonal drug for menopause symptoms passes phase 3 test
The novel NK3 receptor–inhibitor fezolinetant controlled vasomotor symptoms of menopause over 52 weeks in the phase 3 SKYLIGHT 2 trial.
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Prediabetes is linked independently to myocardial infarction
A history of prediabetes is predictor of MI independent of any other risk factor, suggesting that screening efforts should increase.
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Male contraceptive pill appears feasible in very early trials
By lowering testosterone levels without untoward hypogonadism, early data show that once-daily contraceptive pills for men could be feasible.
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New test might transform male infertility
The test detects unstable gene promotors, which are the epigenetic markers for gene expression.