News
Step-down etanercept fails to control ankylosing spondylitis
Key clinical point: All the patients who did not maintain disease control after halving their dose of etanercept were able to regain clinical...
News
Biologic agents do not up recurrent cancer risk in RA
Major finding: Age- and sex-adjusted hazard ratios for recurrent cancer vs. nbDMARDs were 0.55 for anti-TNFs and 0.47 for rituximab.
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Anti-TNFs linked to lower heart attack risk in RA patients
Key clinical point: Linkage of BSRBR-RA Register data with a database of MIs in England and Wales further solidifies the evidence for lower risk...
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Simeprevir and sofosbuvir combo offers high SVR rates
Major finding: SVR12 rates were 93% and 93% after 12 weeks and 93% and 100% after 24 weeks of dual treatment with or without ribavirin.Data source...
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All-oral, triple-acting HCV regimen cures more than 90% of cirrhotic cases
Major finding: Sustained virologic responses 12 weeks after treatment was stopped were 91.8% and 96.1%, respectively, with a 12-week and a 24-week...
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Simvastatin improves survival in cirrhosis-linked variceal bleeding
Key clinical point: Simvastatin should be recommended in patients on secondary prophylaxis of variceal bleeding, especially in those with Child-...
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Antiviral combo pill cures HCV in 8-12 weeks
Key clinical point: A sofosbuvir-ledipasvir combination tablet can be used in almost all genotype 1 patients with a short duration of 8-12 weeks...
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Obeticholic acid shows promise in primary biliary cirrhosis
Major finding: The combined primary endpoint of reduction in ALP and bilirubin was achieved by 46%-47% of obeticholic acid (OCA)- and 10% of...
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Vision test has additive effect on concussion detection in athletes
Major finding: 89%-100% of concussive injuries were identified when the King-Devick test was combined with standard concussion tests.Data source:...
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Persistent depression doubled coronary heart disease risk
Major finding: Depressive symptoms present at three to four observation points were associated with a hazard ratio of 2.06 for coronary heart...
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Teriflunomide cuts annual MS relapse rate more than a third
Major finding: The annualized relapse rate was 0.32 for patients treated with teriflunomide 14 mg versus 0.50 for placebo-treated patients (P = ....
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Fecal immunochemical tests detect most colorectal cancers
Major finding: Fecal immunochemical tests are 79% sensitive and 94% specific, with an overall diagnostic accuracy of 95%.Data source: Systematic...
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Seemingly pan-negative melanomas may be sensitive to MEK inhibitor
Major finding: Between 4% and 8% of pan-negative melanomas harbor gene fusions involving BRAF and are sensitive to MEK inhibitor treatment.Data...