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NLR correlates with survival in advanced breast cancer
Key clinical point: Neutrophil lymphocyte ratio (NLR) can be correlated with poor disease-specific survival in stage IV breast cancer and the...
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No survival difference between continuous and intermittent ADT
Key clinical point: Intermittent androgen deprivation is not inferior to continuous therapy in regards to overall survival.
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Reovirus ready for clinical testing in CLL
Key clinical point: Reovirus, a naturally occurring oncolytic virus, in combination with anti-CD20 immunotherapy, may have benefit for the...
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Mutation testing aids CML treatment decisions
Key clinical point:Mutation testing may aid treatment selection in patients with chronic myeloid leukemia (CML) when selecting an alternative...
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Whole-exome sequencing reveals important mutations in myeloma
Whole-exome sequencing of the patients with myeloma identified 15 significantly mutated genes. With the exception of NRAS and KRAS, the other...
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GM-CSF did not increase survival in high-risk melanoma
Key clinical point: Adjuvant granulocyte macrophage colony-stimulating factor and peptide vaccination did not significantly improve relapse-free...
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Early results encouraging for nivolumab in ovarian cancer patients
Key clinical point: Nivolumab demonstrated encouraging clinical efficacy and tolerability in patients with platinum-resistant ovarian cancer....
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Obinutuzumab trends better than rituxumab in relapsed indolent lymphoma
Key clinical point: Obinutuzumab was associated with a higher overall response rate as compared with rituximab, but obinutuzumab’s clinical...
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CLL patients achieve remission with CAR-modified T-cells
Key clinical point: CAR-modified T cell therapy lacks the toxicities and limitations of allogeneic stem cell transplantation and may be an...
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Low-risk prostate cancer: Replace immediate intervention with immediate contemplation
Key clinical point: Men with favorable-risk prostate cancer have a low risk of progression to a lethal phenotype and should consider active...
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Persistent mutations linked to poorer outcomes in AML
Key clinical point: Leukemia-associated mutations that persisted 30 days after chemotherapy initiation were associated with a significantly...
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Lenalidomide + rituximab combo effective in recurrent follicular lymphoma
Key clinical point: Lenalidomide combined with rituximab is more active in recurrent follicular lymphoma, compared with lenalidomide monotherapy....
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Continuous therapy improved outcomes in multiple myeloma
Key clinical point: Continuous therapy improved outcomes in multiple myeloma, compared with fixed duration therapy. Major finding: Overall...
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Weight program effective for breast cancer survivors
Key clinical point: A group-based behavioral weight loss intervention can lead to clinically meaningful weight loss in overweight/obese breast...
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Novel triple therapy in ITP provides enduring responses
A novel combination of dexamethasone, cyclosporine, and rituximab was well tolerated in patients with chronic ITP, and significantly increased...