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Abiraterone also benefits low-risk metastatic prostate cancer patients
MUNICH – Analyses of STAMPEDE trial data using risk criteria from two other trials revealed distinct survival benefits with abiraterone, ADT, and...
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Study supports PBM program for HSCT recipients
BOSTON—A blood management program for patients undergoing hematopoietic stem cell transplant (HSCT) can reduce inappropriate transfusions and...
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PBM saves blood, costs in HSCT unit
BOSTON – Blood-product use declined, with no negative effects on patients outcomes, following the start of a patient blood management program.
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Capmatinib active against NSCLC with MET exon 14 mutations
MUNICH – Patients with MET exon 14–skipping mutations, but not MET gene amplification, had a high response rate to capmatinib.
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Aberrant RNA editing linked to aggressive myeloma
Hyper-editing of the multiple myeloma transcriptome leads to crippling of a key DNA-repair mechanism.
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Changes related to AML relapse may be reversible
New research suggests relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplant (HSCT) is related to changes in...
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Venetoclax/HMA combo still safe, effective for elderly with AML
The combination was associated with good response rates in patients aged 75 years and older and those with poor-risk cytogenetics.
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AML relapse after HSCT linked to potentially reversible immune changes
Epigenetic changes that weaken the immune response appear to allow leukemic cells to escape surveillance after stem cell transplant for AML.
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Pembrolizumab extends survival of head and neck cancer
MUNICH – Pembrolizumab was associated with longer overall survival and more durable responses than was cetuximab-based chemotherapy.
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Nivo + ipi shows durable activity against metastatic melanoma
MUNICH – Four-year data from the Checkmate 067 study bolster earlier findings supporting the checkpoint inhibitor combination in first line...
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Testing platelets reduces waste, cuts costs
BOSTON—Rapid bacterial testing of platelets in a hospital blood bank can result in both significant cost savings and reduced wastage of blood...
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Rapid bacterial testing of platelets saves money, reduces waste
BOSTON – Annual costs savings approached $89,000 and fewer units of platelets were discarded because of expiration.
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Worse OS, control of low-risk oropharyngeal cancer with cetuximab
Toxicities were similar, but overall survival and disease control in patients with HPV-positive low-risk cancer was worse with cetuximab versus...
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SOLAR-1 shines light on PI3K in breast cancer
MUNICH – The selective PI3K inhibitor added to fulvestrant extended progression-free survival in breast cancer patients with PIK3CA mutations.
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STAMPEDE: Radiation to prostate boosts survival of metastatic cancer
MUNICH – Patients with low-burden metastatic prostate cancer had an 8% 3-year survival benefit when they received radiation plus androgen...