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Gut bacteria influence HCT outcomes
SAN DIEGO – Gut microbiome diversity predicts overall survival after hematopoietic cell transplant.
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JULIET: CAR T cells keep trucking against DLBCL
SAN DIEGO – Median overall survival for patients with complete responses to CAR T-cell therapy was not reached through 19 months of follow-up.
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FLYER: Four cycles of R-CHOP as good as six in low-risk DLBCL
SAN DIEGO – Survival outcomes were nearly identical and adverse events were lower with four versus six cycles of R-CHOP in patients with favorable...
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FLYER: R-CHOP 4 safer, as effective for low-risk DLBCL patients under 60
SAN DIEGO – Progression-free, event-free, and overall survival were comparable with that of patients assigned to six cycles of therapy.
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Sickle cell disease phenotype reversed by gene therapy
SAN DIEGO – Genetically modified autologous stem cells increased protective fetal hemoglobin and decreased sickle hemoglobin in an adult with...
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Flipping the fetal hemoglobin switch reverses sickle cell symptoms
SAN DIEGO – One adult with sickle cell disease had near-complete remission of symptoms after 6 months of follow-up.
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Cortactin expression aids in CLL-MCL differential
Cortactin, a cytoskeleton-remodeling adapter protein, is expressed on most CLL cells, but not similar-appearing MCL cells.
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ASH 2018 coming attractions look at the big picture
Big trials, big results in malignant and nonmalignant hematologic disorders are on the program at the 2018 ASH annual meeting.
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BAP1 expression augurs prognosis of metastatic RCC
Discordant gene expression results between primary tumors and metastases reveal a need for prognostic biomarkers in metastases.
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PD-L1 correlates with worse sporadic, hereditary ccRCC outcomes
Patients with sporadic clear cell renal cell carcinomas expressing PD-L1 had worse disease-free survival.
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R-CHOP effective as first-line treatment in FL
Long-term data suggest R-CHOP can be effective as first-line treatment for patients with follicular lymphoma (FL). In a phase 2-3 trial,...
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R-CHOP looks viable as first line in follicular lymphoma
Long-term follow-up of a randomized trial showed durable efficacy of R-CHOP with no increase in histological transformation or secondary cancers...
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Preoperative anemia management saves blood, money
BOSTON—Results of a pilot program suggest preoperative management of anemia can reduce transfusion rates and cut costs, but the effect on patient...
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Preop anemia management saves blood, costs
BOSTON – Managing anemia prior to cardiac surgery saved a hospital more than $100,000 in transfusion costs in a pilot program.
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ADAR1 linked to MM pathogenesis, outcomes
Overly zealous editing of messenger RNA in multiple myeloma (MM) cells contributes to MM pathogenesis and is associated with poor outcomes after...