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Mepolizumab proves effective for eosinophilic granulomatosis with polyangiitis
The anti–interleukin-5 monoclonal antibody beat placebo for total accrued weeks of remission and remission after 36 and 48 weeks of treatment.
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Oral iron of no benefit in heart failure with iron deficiency
High-dose oral iron therapy doesn’t improve exercise capacity in the estimated 50% of patients with symptomatic heart failure who also have iron...
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Corticosteroids effective just hours before preterm delivery
A simulation model predicts that antenatal corticosteroids given just 3 hours before a preterm delivery could reduce the mortality risk.
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Deep infiltrating endometriosis lesions harbor cancer-driver mutations
A finding of cancer-related mutations in noncancerous lesions is “surprising” and raises new questions about the pathobiology of endometriosis.
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Isothiazolinone allergy frequent and underdiagnosed in children
An allergy to isothiazolinones, often used as preservatives in various personal and household products, frequently may be missed in children.
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USPSTF: No thyroid cancer screening for asymptomatic adults
The harms of screening asymptomatic adults for thyroid cancer outweigh the benefits, according to the U.S. Preventive Services Task Force.
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Subcutaneous rituximab safe, effective for follicular lymphoma
Efficacy and safety profiles were similar for subcutaneous and standard IV rituximab when given as first-line therapy to adults with follicular...
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Updated osteoporosis guideline advocates bisphosphonates, nixes estrogens
Even though well-designed, randomized controlled trials amply demonstrate the effectiveness of bisphosphonates in preventing fractures,...
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Breast milk bacteria seed infant gut microbiome
Researchers have found that good bacteria from mothers’ milk and skin are transferred to infants’ guts.
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AGA Clinical Practice Update: Expert review recommendations on post-SVR hepatitis C care
Attention should be paid to fibrosis, cirrhosis, esophagogastric varices, and factors that could contribute to liver injury or hepatic...
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Longer course of idarubicin consolidation increases leukemia-free survival
A more intensive course of idarubicin with consolidation therapy improved leukemia-free survival and increased the time to relapse.
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Maintenance lenalidomide prolongs progression-free survival in DLBCL
Progression-free survival improved with lenalidomide maintenance in DLBCL among elderly patients.
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FDA boxed warning leads to drop off in use of ESAs
The FDA warning language was linked with a sharp decrease in use of erythropoietin-stimulating agents in colorectal, breast, and lung cancer...
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TNFSF13B variant linked to MS and SLE
A variant in the TNFSF13B gene has been linked to susceptibility to both multiple sclerosis and systemic lupus erythematosus, according to a...
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USPSTF says check BP at each visit to screen for preeclampsia
Evidence for preeclampsia risk prediction tools is limited, so the USPSTF advises physicians to stick with regular blood pressure screening.