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Sickle cell trait doesn’t increase risk of death, study suggests
Results of a large study contradict the view that having sickle cell trait increases a person’s risk of death. Health records of nearly 50,000...
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Improving upon results with checkpoint inhibitors
Photo by Rob Press Manipulating metabolic events might reinvigorate exhausted T cells and complement the effects of checkpoint inhibitors in the...
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Many pediatric trials go unfinished, unpublished
Clinical trials in children too often go uncompleted or unpublished, according to a pair of researchers. The duo evaluated nearly 560 pediatric...
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Docs prescribe drugs despite possible interaction
Photo by Rhoda Baer Physicians may still prescribe a controversial drug combination despite safety concerns, according to a study published in...
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Overcoming drug resistance in malaria
infecting a red blood cell Photo courtesy of St.
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Method provides more accurate diagnosis of MDS, team says
Next-generation sequencing (NGS) of cell-free DNA should be the method of choice to confirm the diagnosis of myelodysplastic syndromes (MDS),...
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How iPSCs differentiate to blood cells
Image from Salk Institute New research suggests the type of founder cell used to generate induced pluripotent stem cells (iPSCs) does not affect...
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Gene therapy reduces need for FIX prophylaxis
Image courtesy of NIGMS ORLANDO—The gene therapy AMT-060 can reduce the need for factor IX (FIX) prophylaxis in patients with severe hemophilia B...
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Microneedle system could replace blood draws, team says
Photo courtesy of Sahan Ranamukhaarachchi A new microneedle drug monitoring system could one day replace invasive blood draws, according to...
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FDA approves reconstitution system for FVIII product
Photo courtesy of Baxalta The US Food and Drug Administration (FDA) has approved the Baxject III reconstitution system for Adynovate, a pegylated...
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HDAC inhibitor granted breakthrough designation
Image by Eric Smith The US Food and Drug Administration (FDA) has granted breakthrough therapy designation for the histone deacetylase (HDAC)...
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Molecule reverses effects of anticoagulants
A genetically engineered coagulation factor can reverse the effects of direct oral anticoagulants in vitro and in vivo, according to research...
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Gene therapy shows promise for severe hemophilia A
Image by Spencer Phillips ORLANDO—An investigational gene therapy can safely reduce bleeding in patients with severe hemophilia A, a phase 1/2...
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Targeted conjugate therapy kills ALL cells
Photo courtesy of the University of California Davis Researchers say they have developed a targeted conjugate therapy that harnesses a monoclonal...
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Local Zika transmission and the US blood supply
Photo courtesy of Muhammad Mahdi Karim Officials have announced what is likely the first known occurrence of local mosquito-borne Zika virus...