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A decade after the CATIE study, the focus has shifted from effectiveness to neuroprotection
This past September, exactly 10 years after publication of the primary findings of the Clinical Antipsychotic Trials of Intervention Effectiveness...
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Needed: A biopsychosocial ‘therapeutic placenta’ for people with schizophrenia
Schizophrenia and stroke are 2 serious brain disorders that involve brain damage and disability. Yet the difference between the 2 disorders is...
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Do you practice sophisticated psychiatry? 10 Proposed foundations of advanced care
Progress in scientific and clinical knowledge of psychiatry is proceeding at a furious pace.
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Managing first-episode psychosis: Rationale and evidence for nonstandard first-line treatments for schizophrenia
Consider long-acting injectable antipsychotics; use clozapine as second- or third-line therapy only. Second of 2 parts.
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Is there only 1 neurobiologic psychiatric disorder, with different clinical expressions?
The nearly 1,000-page DSM-5 lists hundreds of psychiatric disorders, with an operational clinical process to distinguish them.
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Beyond dopamine: Brain repair tactics in schizophrenia
Let’s be honest: No one is satisfied with current treatment outcomes in schizophrenia.
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Managing first-episode psychosis: An early stage of schizophrenia with distinct treatment needs
Minimize duration of untreated psychosis; aim for remission
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Psychoneurogastroenterology: The abdominal brain, the microbiome, and psychiatry
Existence of a gastrointestinal (GI) nervous system, distinct from the CNS that comprises the brain and spinal cord, has been recognized for more...
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Unmet needs and hassles of psychiatric practice
Few things are more aggravating than having to secure preauthorization from an insurance company to hospitalize an acutely ill patient or to...
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10 Triggers of inflammation to be avoided, to reduce the risk of depression
According to the World Health Organization, depression is one of the most prevalent serious brain disorders and the No. 1 cause of disability in...
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10 Recent paradigm shifts in the neurobiology and treatment of depression
The serendipity of half a century ago that hatched hoary theories of the etiology of psychopathology is fading rapidly. Transformative models are...
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From bedlam to biomarkers: The transformation of psychiatry’s terminology reflects its 4 conceptual earthquakes
I fell in love with psychiatry at age 14. Since then, I have witnessed this medical specialty reinvent itself 4 times. This transformation is...