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Surprising finding in upfront use of idelalisib monotherapy
Photo courtesy of ASH ORLANDO, FL—Investigators have observed early fulminant hepatotoxicity in a subset of primarily younger chronic lymphocytic...
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Group recommends adding rituximab to ALL therapy
Photo courtesy of ASH ORLANDO, FL—Investigators from the Group for Research on Adult Lymphoblastic Leukemia (GRAALL) recommend integrating...
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RATIFY trial results available after almost 10 years in the making
Photo courtesy of ASH ORLANDO, FL—After almost 10 years, during which time no new drug for acute myeloid leukemia (AML) has been approved,...
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ALL patients over-report their 6MP compliance, researchers say
Photo courtesy of ASH ORLANDO, FL—A study comparing subjective versus objective reporting of treatment compliance in patients with acute...
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Breast cancer drug may also work in MCL, myeloma
NEW YORK—Targeting the cell cycle with cyclin-dependent kinase (CDK) inhibitors may be an effective strategy to treat lymphoma and myeloma,...
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Post-ibrutinib management in MCL unclear, speaker says
NEW YORK—Despite an “unprecedented” single-agent response rate and progression-free survival (PFS) in previously treated mantle cell lymphoma (MCL...
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Reprogramming the immune system
showing Hodgkin lymphoma NEW YORK—Using a 3-pronged approach to reprogram the immune system—inhibition of critical pathways, activation of others...
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Median DOR, PFS not yet reached for ibrutinib in CLL
NEW YORK—Long-term follow-up of single-agent ibrutinib at the approved dose of 420 mg daily confirms that the Bruton’s tyrosine kinase inhibitor...
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The search continues for additional targets in CLL
showing CLL Image by Mary Ann Thompson NEW YORK—Despite enormous advances in therapies for chronic lymphocytic leukemia (CLL) that target the B-...
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Ibrutinib may prove useful in MM, research shows
showing multiple myeloma NEW YORK—Results of an open-label, phase 2, dose-escalation study of ibrutinib combined with low-dose dexamethasone...
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Creating off-the-shelf VSTs
Photo courtesy of Baylor College of Medicine NEW YORK—Researchers are creating virus-specific T cells (VST) to treat and prevent viral infections...
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Treating EBV-associated lymphomas with VSTs
among uninfected cells (blue) Image by Benjamin Chaigne-Delalande NEW YORK—Type 2 Epstein-Barr virus (EBV) tumors, such as Hodgkin and non-...
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New chimeric CD19 antibody may reduce MRD in ALL
NEW YORK—Researchers have developed a pharmaceutical-grade, third-generation, CD19-specific antibody that reduced minimal residual disease (MRD)...
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Nonviral gene transfer of CARs tested in humans
Photo courtesy of MDACC NEW YORK—Researchers have used a nonviral approach to create chimeric antigen receptor (CAR) T cells and tested these...
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Abs from transplanted AML patients enhance GvL effect in vitro
NEW YORK—Investigators have found that B cells may play a role in stimulating graft-versus-leukemia (GvL) responses in patients with acute myeloid...