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‘Practice-changing’ treatments emerging in AML
NEW YORK—We are “finally” making progress in the treatment of acute myeloid leukemia (AML), according to a speaker at the NCCN 11th Annual...
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Doc offers advice on choosing a frontline TKI
Photo by D.
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Tandem ASCT for neuroblastoma comes with caveat
CHICAGO—A phase 3 study of tandem autologous stem cell transplant (ASCT) for children with high-risk neuroblastoma has shown that tandem...
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Venetoclax + LDAC has potential in older AML patients
CHICAGO—Investigators are pursuing the combination of the selective BCL-2 inhibitor venetoclax plus low-dose cytarabine (LDAC) in older, treatment...
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Rituximab plus chemo in kids with B-NHL could be practice changing
© ASCO/Matt Herp CHICAGO—The first interim analysis of rituximab plus chemotherapy in children and adolescents with high-risk B-cell non-Hodgkin...
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‘Unprecedented’ efficacy for daratumumab in rel/ref MM
CHICAGO—The addition of the monoclonal antibody daratumumab to bortezomib and dexamethasone, the current standard of care for relapsed/refractory...
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Upfront ASCT still preferred for young MM patients
Photo by Chad McNeeley CHICAGO—An interim analysis of a large, phase 3 study has confirmed that upfront autologous stem cell transplantation (...
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Current cancer drug discovery method flawed, team says
Image courtesy of PNAS The primary method used to test compounds for anticancer activity in vitro may produce inaccurate results, according to...
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Pre-treatment gut bacteria may predict risk of BSI
A new study suggests the composition of a cancer patient’s intestinal microbiome before treatment may predict his risk of developing a bloodstream...
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Frailty in HSCT population not dependent on age
Photo by Peter Griffin ORLANDO, FL—Frailty after hematopoietic stem cell transplant (HSCT), while associated with higher mortality, is not...
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Potential new alternative in CML when TKI therapy fails
ASH Annual Meeting Photo courtesy of ASH ORLANDO, FL—ABL001, an allosteric inhibitor of BCR-ABL1, has shown early evidence of single-agent...
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Osteoarticular pain affects CML patients stopping TKI
Photo courtesy of ASH ORLANDO, FL—Cases of musculoskeletal pain have been reported after patients stop taking tyrosine kinase inhibitors (TKIs)...
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Venetoclax produces deep responses in ultra-high-risk CLL
Photo courtesy of ASH ORLANDO, FL—The pivotal phase 2 study of venetoclax monotherapy in patients with relapsed/refractory 17p-deleted chronic...
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Regimen with intensified PEG-ASP feasible in young adults with ALL
Annual Meeting Photo courtesy of ASH ORLANDO, FL—Results of a DFCI ALL Consortium trial have shown that adults with acute lymphoblastic leukemia...
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SAA patients benefit from upfront eltrombopag combo
Photo courtesy of ASH ORLANDO, FL—Investigators are pursuing an upfront approval for eltrombopag in combination with immunosuppressive therapy...