Erik Greb joined the staff of Neurology Reviews in January 2012. Since then, he has attended scientific conferences, conducted video interviews, and written about clinical research in multiple sclerosis, epilepsy, Parkinson's disease, Alzheimer's disease, stroke, and other neurologic disorders. In addition to news articles, Erik has written investigative stories about multiple sclerosis, headache, and epilepsy. He previously wrote about pharmaceutical manufacturing, drug formulation and delivery, quality assurance, and regulation for Pharmaceutical Technology.
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Newer DMTs are more effective than injectable DMTs in pediatric MS
A retrospective study suggests that the safety and tolerability of newer disease-modifying therapies are the same in children as in adults.
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Cerebral blood flow may predict children’s recovery from persistent postconcussion symptoms
Higher cerebral blood flow at 4-6 weeks post injury is associated with poor recovery at 10 weeks among children with concussion.
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Nusinersen provides continued benefits to presymptomatic children with SMA
Most children developed normally in an interim analysis of the NURTURE trial that did not find any new safety concerns.
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Neutrophil granulocyte markers may distinguish between demyelinating diseases
Evaluating CSF for neutrophil granulocyte markers may help distinguish between MS, neuromyelitis optica spectrum disorders, and anti–myelin...
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Preventive treatment delays first seizure onset in tuberous sclerosis complex
Administering vigabatrin before the first seizure may reduce the risk and severity of epilepsy, compared with conventional treatment.
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Comorbidity burden is greater among children with tics than children with stereotypies
Among children, tics are associated with a higher number of neurologic consultations and a greater likelihood of pharmacologic or behavioral...
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Bacteria may be associated with risk of MS relapse
A study of patients with pediatric-onset MS suggests that methanogenesis pathways may play a role in the risk of relapse.
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Women with MS may have increased subclinical disease activity during pregnancy
Serum levels of neurofilament light increase among women with MS during pregnancy and the postpartum period.
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Researchers identify five cognitive phenotypes in MS
Clinical and imaging examinations suggest discrete profiles of cognitive dysfunction with distinct neuroanatomical foundations.
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High plasma GFAP level predicts disability accumulation in secondary progressive MS
The GFAP level may be a stronger predictor in women and in patients with nonactive disease, compared with active disease.
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Satralizumab reduces risk of severe NMOSD relapse
The treatment also was linked to a lower likelihood of receiving acute relapse therapy, but the study’s sample size was low.
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Exposure to DMT may delay disability accumulation in primary progressive MS
Longer exposure to treatment is associated with a reduced risk of being restricted to a wheelchair in this patient population.
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Mortality burden of dementia may be greater than estimated
The mortality burden of dementia may be highest among non-Hispanic black people, compared with people of other races.
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Alzheimer’s disease may affect sleep patterns
Disturbed sleep does not appear to cause Alzheimer’s disease and Alzheimer’s disease does not appear to cause major depressive disorder.
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Concussion linked to risk for dementia, Parkinson’s disease, and ADHD
A history of multiple concussions strengthened the association between concussion and subsequent mood and anxiety disorder, dementia, and...