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Ibrutinib linked to hypertension in B-cell malignancies
New or worsening hypertension was also linked with a greater risk of major adverse cardiac events.
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Adverse cytogenetics trump molecular risk in NPM1-mutated AML
The findings have implications for postremission treatment decisions, including whether NPM1-mutated patients should receive allogeneic...
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Monthly and twice monthly emicizumab dosing safe for children with severe hemophilia A
The small study confirms the safety of twice-monthly or monthly emicizumab administration for children with severe hemophilia A without inhibitors...
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New consensus recommendations on bleeding in acquired hemophilia
The key areas addressed in the global expert consensus statement include the initial management of bleeding and management of location-specific...
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Eltrombopag elicits positive responses in secondary ITP
The drug appears safe among patients with ITP secondary to lymphoproliferative disorders, but more study is needed to determine the potential risk...
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Novel research aims to improve ED care in sickle cell disease
Researchers are testing the best acute pain management strategies to respond to a vasoocclusive crisis.
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Apple cider vinegar soaks fall short in atopic dermatitis
Acetic acid, particularly apple cider vinegar, has become prominent among emerging natural remedies for atopic dermatitis.
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Ongoing research aims to improve transplant outcomes in sickle cell
Over the past 2 years, the majority of novel transplant techniques have been primarily aimed at improving conditioning regimens and lowering rates...
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A quarter of ICU admissions caused by substance abuse
Polysubstance abuse was the most frequent subcategory of illicit and prescription drug admissions.
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Novel gene therapies show promise for sickle cell cure
Gene-addition and gene-editing therapies are currently in clinical development.
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Genetic analysis highlights value of germline variants in MDS, AML
Systematic genetic testing for DDX41 mutations may aid in clinical decision making for adults with MDS or AML.
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Study confirms prognostic impact of MYC partner gene in DLBCL
The findings suggest that clinicians should adopt diagnostic strategies to identify this high-risk cohort of patients.
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VRD pretransplant induction deepens responses in myeloma
The researchers wrote that the unique dosing of the three-drug induction regimen may be considered a new standard of care.
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Metformin-TKI combo improves PFS in EGFR-mutated lung cancer
Combination metformin and epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR-TKI) therapy improved progression-free survival in...
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Rituximab, bendamustine look better than chemo alone in MCL
The research confirms the benefit of adding novel agents to chemotherapy regimens in older patients with mantle cell lymphoma.