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Lentiviral gene therapy appears effective in X-CGD
HOUSTON – Results from the small study provide a “proof of concept” for the use of gene therapy in X-linked chronic granulomatous disease,...
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Report: Cutting sodium consumption recommended
The first-ever Dietary Reference Intakes (DRIs) measure specific to chronic disease risk reduction has been unveiled.
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No increased pregnancy loss risk for women conceiving soon after stillbirth
There was no significantly increased risk of stillbirth, preterm birth, or small-for-gestational-age birth in the next pregnancy for women who...
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Sperm counts largely stable after adjuvant treatment of clinical stage I testicular cancer
Sperm count and concentration remained stable or increased in patients with clinical stage I testicular cancer who underwent unilateral...
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Delaying antibiotics in elderly with UTI linked to higher sepsis, death rates
Older patients who were prescribed antibiotics immediately after a UTI diagnosis had the best outcomes in a large study.
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FDA: Safety signal emerged with higher dose of tofacitinib in RA study
The FDA is working with Pfizer to better understand how the signal affects patients and how the drug should be used, the agency said in a...
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ZUMA-1 update: Axi-cel responses persist at 2 years
HOUSTON – Median duration of response and overall survival have not yet been reached in the pivotal CAR T-cell therapy trial.
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Dual-targeted CAR T shows ‘clinical signal’ in NHL
HOUSTON – Due to local manufacturing of the CAR T-cell therapy, most patients were able to receive fresh, rather than cryopreserved, product.
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MRD negativity linked to survival in MM after auto-HCT
HOUSTON – MRD-negative status was prognostic for improved progression-free survival at all time points measured after transplant.
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Anti-GM-CSF antibody reduced CAR T-cell toxicity
HOUSTON – An early study shows the potential of lenzilumab to reduce CAR T-cell toxicity.
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Treosulfan may become standard in allo-HCT for AML/MDS
HOUSTON – A treosulfan-based myeloablative conditioning regimen was noninferior to the reduced intensity busulfan-based regimen in event-free...
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Ultrasound method predicts liver complications in pediatric transplant
HOUSTON – Using shear wave elastography predicted disease at least 4 days before standard diagnostic criteria in most patients.
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AACE/ACE algorithm provides practical clinical guidance on managing diabetes
Update provides new clinical guidance for managing diabetes and highlights obesity and prediabetes as underlying risk factors
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PTSD, cardiovascular disease link likely caused by higher comorbidity burden
Psychological morbidities and smoking are contributors to cardiovascular disease outcomes.
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DAAs reduce mortality, cancer risk in HCV study
Large, prospective study showed direct-acting antivirals reduced mortality and cancer risk in chronic HCV-infected patients.