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Dabrafenib plus trametinib yields long-term benefit in melanoma patients
A long-term survival benefit was seen in about a third of patients with metastatic or unresectable melanoma who underwent first-line treatment...
Article
Novel translocation inhibitor shows efficacy in treatment-naive HIV-1–infected adults
Potent, first-in-class antiretroviral drug may eventually allow for once-weekly or once-monthly dosing, investigator says.
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Antiretroviral-eluting implant could provide HIV prophylaxis for a year or more
The long-term islatravir implant could one day provide an easier adherence alternative for many.
Article
Two-drug integrase inhibitor–based regimen noninferior to standard in HIV-infected adults
In light of these findings and those from other studies, it may be time to “rethink the position of dual therapy in the international guidelines...
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POEM outperforms pneumatic dilation in randomized achalasia trial
Higher success rate, but also a higher rate of reflux esophagitis, seen in patients with previously untreated achalasia.
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Colorectal cancer diagnoses still moving up in younger adults, with no sign of plateau
Incidence increased from 10% to 12% over a decade in the analysis of a large U.S. cancer registry.
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Systolic, diastolic BP each tied to adverse CV outcomes
Diastolic hypertension can’t be ignored, investigator says, though systolic ultimately has a larger impact.
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Obesity tied to relapse in young patients with multiple sclerosis
Weight loss or BMI-based dosing might improve treatment response.
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C-reactive protein testing reduced antibiotic prescribing in patients with COPD exacerbation
Fewer prescriptions, less reported antibiotic use, with no evidence of harm or reduced quality of life, according to PACE trial investigators.
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Recombinant vaccine cut herpes zoster rate in immunocompromised patients
In a randomized clinical trial of 1,846 adults who had undergone autologous HSCT, herpes zoster cases were seen in 49 and 136 individuals in the...
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Round 1: Biologics, JAK inhibitors training up for atopic dermatitis ‘boxing match’
MILAN – Safety, mode of action, and price are just a few variables that distinguish these molecules in the ring.
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Study: Most patients hospitalized with pneumonia receive excessive antibiotics
Odds of adverse events increased by 5% per excess day of antibiotic treatment.
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Lipoprotein(a) levels tied to higher ischemic stroke risk
High levels of lipoprotein(a) [Lp(a)] and LPA genotypes were linked to increased ischemic stroke risk in a recent large, contemporary general...