Article
A truly deadly quartet: Obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia
The best available treatment is to control one's weight, exercise regularly, stop smoking, and eat a healthy diet.
Editorial
The metabolic syndrome: A tug-of-war with no winner
Cleveland Clinic Journal of Medicine. 2002 December;69(12):990-994
Author and Disclosure Information
Daniel J. Brotman, MD
Department of General Internal Medicine, The Cleveland Clinic
John P. Girod, DO
Department of General Internal Medicine, The Cleveland Clinic
Address: Daniel J. Brotman, MD, Department of General Internal Medicine, E13, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195; e-mail: brotmad@ccf.org
ABSTRACTThe metabolic syndrome may be viewed as a state of insulin-counterregulatory overdrive: counterregulatory hormones and fatty acids chronically duel with insulin, causing a cascade of biochemical interactions resulting in insulin resistance, hypertension, and dyslipidemia. Even before beta cells fail and type 2 diabetes ensues, the deadly quartet is quietly rehearsing.
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Who is conducting the deadly quartet?
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- Brian F. Mandell, MD, PhD
The metabolic syndrome warrants aggressive intervention and prevention, even if we cannot explain it yet.