Case Reports
Transient Osteoporosis of the Hip in Association With Osteogenesis Imperfecta: Two Cases, One Complicated by a Femoral Neck Fracture
Am J Orthop. 2008 February;37(2):88-91
Author and Disclosure Information
Samuel D. Young III, MD, Charles L. Nelson, MD, and Marvin E. Steinberg, MD
Dr. Young is Assistant Professor, Department of Orthopedic Surgery, University of Florida School of Medicine, Jacksonville, Florida. He was Chief Resident, Department of Orthopedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, at the time the article was written.
Dr. Nelson is Associate Professor, and Dr. Steinberg is Professor Emeritus, Department of Orthopedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Introductory paragraphs provided in lieu of abstract.
Transient osteoporosis of the hip, a relatively uncommon cause of disabling hip pain, occurs spontaneously in men during the fourth and fifth decades of life and in childbearing females during the third trimester of pregnancy. It has been described in conjunction with osteogenesis imperfecta in 18 cases to date. Meta-analysis has suggested that people with osteogenesis imperfecta (vs the general population) are at increased risk for developing transient osteoporosis, suggesting the role of microfractures in the etiology of transient osteoporosis.
In this report, we present 2 additional cases of transient osteoporosis of the hip in conjunction with osteogenesis imperfecta, including the first case of a spontaneous pathologic fracture in a male patient with both disorders.