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Recent Fractures Linked with Lower BMD in Women
J Bone Miner Res; ePub 2017 Nov 8; Rozental, et al
Women with recent hip fracture (HF) or distal radius fracture (DRF) had significantly lower bone mineral density (BMD) than non-fracture controls (CONT) at all sites, according to a recent study. Researchers enrolled postmenopausal women with recent DRF (n=57), HF (n=41), or CONT (n=93), and used impact microindentation to assess bone material strength index (BMSi) at the anterior surface of the mid-tibia diaphysis. Areal BMD (g/cm2) of the femoral neck (FN), total hip (TH), and lumbar spine (LS) were measured by dual-energy X-ray absorptiometry (DXA). They found:
- BMSi was 4% lower in DRF compared to CONT (74.36 ± 8.77 vs 77.41 ± 8.79).
- BMSi was similarly lower in HF vs CONT, but the difference did not reach statistical significance (74.62 ± 8.47 vs 77.41 ± 8.79).
- Lower BMSi was associated with increased risk of DRF, and remained statistically significant after adjustment for age; age and body mass index (BMI); and age, BMI, and FN BMD.
- Lower BMSi tended to be associated with HF, but only reached borderline significance.
Rozental TD, Walley KC, Demissie S, et al. Bone material strength index as measured by impact microindentation in postmenopausal women with distal radius and hip fractures. [Published online ahead of print November 8, 2017]. J Bone Miner Res. doi:10.1002/jbmr.3338.