Interventions promoting moderate physical activities may be most beneficial to address pain among people with or at high risk for knee osteoarthritis (OA), a recent cross-sectional study found. In addition to encouraging moderate-intensity physical activity, pain management strategies may also include the identification and treatment of sleep problems. Researchers used isotemporal logistic regression models to examine the estimated effect on pain from replacing time in one behavior with equal time in another, controlling for sociodemographic and health factors. Stratified analysis was conducted by the report of restless sleep. Sleep and wake behaviors (sedentary behavior, light physical activity [PA], moderate PA) were monitored by accelerometer in a pilot study of 185 Osteoarthritis Initiative participants. Outcomes were bodily pain interference and knee pain. They found:

• Moderate PA substituted for an equivalent time in sleep or other types of wake behaviors was most strongly associated with lower odds of pain (bodily pain interference odds reduced 21%-25%, knee pain odds reduced 17%-20% per 10-minute exchange).
• These beneficial associations were particularly pronounced in individuals without restless sleep, but not in those with restless sleep, especially for bodily pain interference.