“This was a Herculean effort that was timely and appropriate, given the rising interest in fibromyalgia as a common condition that needs more attention,” he said.
Another fibromyalgia expert, Dr. Robert M. Bennett of Oregon Health and Science University, Portland, offered a caution about pharmacotherapy in fibromyalgia. For instance, no mention is made of sleep medications or the adverse interactions of medications. “Tramadol has a dual action, as a weak opioid and a serotonin and norepinephrine reuptake inhibitor, and may interact with antidepressants, especially the monoamine oxidase inhibitors moclobemide and pirlindole, to induce a serotonin syndrome,” Dr. Bennett explained in an interview.
The guidelines will be updated every 5 years, with the hope that good quality clinical trials will continue to add to the available evidence, wrote the investigators.
'Both pregabalin and pramipexole are recommended, but if you look at the specific trials they are vastly different.' DR. MEASE