Key clinical point: Neuropathic pain (NP) led to an increase in obesity-associated factors, such as high serum leptin levels and worsened sleep quality, disease activity outcomes, and fatigue levels in patients with psoriatic arthritis (PsA) who did not have fibromyalgia.
Major finding: Patients with PsA who reported NP vs nociceptive pain had higher serum leptin levels (odds ratio [OR] 1.03; 95% CI 1.007-1.056) and poor sleep quality as assessed by the Insomnia Severity Index score (OR 1.19; 95% CI 1.090-1.297), along with greater fatigue, increased PsA disease activity, poor functioning, and higher disease impact (all P < .001).
Study details: Findings are from a cross-sectional study that included 246 patients with PsA who were not diagnosed with fibromyalgia, depression, anxiety, diabetes, or dyslipidemia.
Disclosures: The study authors declared receiving financial support for the research, authorship, and publication of this study. The authors declared no conflicts of interest.
Source: Toledano E, Queiro R, Gomez-Lechon L, et al. Influence of comorbidities not associated with fibromyalgia on neuropathic pain in patients with psoriatic arthritis: Relationship with clinical parameters. Front Med (Lausanne). 2024;11:1331761 (Jan 24). doi: 10.3389/fmed.2024.1331761 Source