Evidence-Based Reviews

Do cholinesterase inhibitors enhance cognition in schizophrenia?

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References

  • when other adjuncts have failed
  • as a supplement to other augmentation strategies, such as cognitive-behavioral therapy or family therapy.
Related resources
  • Mohamed S, Paulsen JS, O’Leary D, et al. Generalized cognitive deficits in schizophrenia. Arch Gen Psychiatry 1999;56:749-54.
  • Risch SC, Horner MD, McGurk S, et al. Double-blind donepezil-placebo crossover augmentation study of atypical antipsychotics in chronic, stable schizophrenia: a pilot study. Schizophr Res 2007;93:131-5.
Drug brand names
  • Donepezil • Aricept
  • Rivastigmine • Exelon
  • Galantamine • Reminyl, Razadyne
  • Ziprasidone • Geodon
Disclosure

Dr. Risch receives research support from the National Institute of Mental Health, Abbott Laboratories, GlaxoSmithKline, Bristol-Myers Squibb, and Forest Pharmaceuticals. He is a consultant to and speaker for AstraZeneca and Pfizer Inc.

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