From the Editor

Psychiatry is Neurology: White matter pathology permeates psychiatric disorders

Current Psychiatry. 2021 June;20(6):7-10 | doi:10.12788/cp.0138

References

1. Sagarwala R and Nasrallah HA. White matter pathology is shared across multiple psychiatric brain disorders: Is abnormal diffusivity a transdiagnostic biomarker for psychopathology? Biomarkers in Neuropsychiatry. 2020;2:00010. https://doi.org/10.1016/j.bionps.2019.100010
2. Pearce JMS; FRCP. The “split brain” and Roger Wolcott Sperry (1913-1994). Rev Neurol (Paris). 2019;175(4):217-220.
3. Nasrallah HA, Andreasen NC, Coffman JA, et al. A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biol Psychiatry. 1986;21(3):274-282.
4. Nasrallah HA, McChesney CM. Psychopathology of corpus callosum tumors. Biol Psychiatry. 1981;16(7):663-669.
5. Nasrallah HA. The unintegrated right cerebral hemispheric consciousness as alien intruder: a possible mechanism for Schneiderian delusions in schizophrenia. Compr Psychiatry. 1985;26(3):273-282.
6. Friston K, Brown HR, Siemerkus J, et al. The dysconnection hypothesis (2016). Schizophr Res. 2016;176(2-3):83-94.
7. Najjar S, Pearlman DM. Neuroinflammation and white matter pathology in schizophrenia: systematic review. Schizophr Res. 2015;161(1):102-112.
8. Benedetti F, Bollettini I. Recent findings on the role of white matter pathology in bipolar disorder. Harv Rev Psychiatry. 2014;22(6):338-341.
9. Zheng H, Bergamino M, Ford BN, et al; Tulsa 1000 Investigators. Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder. Neuropsychopharmacology. 2021;46(5):928-938.
10. Sagarwala R, Nasrallah HA. A systematic review of diffusion tensor imaging studies in drug-naïve OCD patients before and after pharmacotherapy. Ann Clin Psychiatry. 2020;32(1):42-47.
11. Lee KS, Lee SH. White matter-based structural brain network of anxiety. Adv Exp Med Biol. 2020;1191:61-70.
12. Swanson MR, Hazlett HC. White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies. J Neurodev Disord. 2019;11(1):33.
13. Hampton WH, Hanik IM, Olson IR. Substance abuse and white matter: findings, limitations, and future of diffusion tensor imaging research. Drug Alcohol Depend. 2019;197:288-298.
14. Waller R, Dotterer HL, Murray L, et al. White-matter tract abnormalities and antisocial behavior: a systematic review of diffusion tensor imaging studies across development. Neuroimage Clin. 2017;14:201-215.
15. Wolf RC, Pujara MS, Motzkin JC, et al. Interpersonal traits of psychopathy linked to reduced integrity of the uncinate fasciculus. Hum Brain Mapp. 2015;36(10):4202-4209.
16. Puzzo I, Seunarine K, Sully K, et al. Altered white-matter microstructure in conduct disorder is specifically associated with elevated callous-unemotional traits. J Abnorm Child Psychol. 2018;46(7):1451-1466.
17. Finger EC, Marsh A, Blair KS, et al. Impaired functional but preserved structural connectivity in limbic white matter tracts in youth with conduct disorder or oppositional defiant disorder plus psychopathic traits. Psychiatry Res. 2012;202(3):239-244.
18. Li C, Dong M, Womer FY, et al. Transdiagnostic time-varying dysconnectivity across major psychiatric disorders. Hum Brain Mapp. 2021;42(4):1182-1196.
19. Khanbabaei M, Hughes E, Ellegood J, et al. Precocious myelination in a mouse model of autism. Transl Psychiatry. 2019;9(1):251.
20. Petratos S, Theotokis P, Kim MJ, et al. That’s a wrap! Molecular drivers governing neuronal nogo receptor-dependent myelin plasticity and integrity. Front Cell Neurosci. 2020;14:227
21. Fernandez-Enright F, Andrews JL, Newell KA, et al. Novel implications of Lingo-1 and its signaling partners in schizophrenia. Transl Psychiatry. 2014;4(1):e348. doi: 10.1038/tp.2013.121
22. Bartzokis G, Lu PH, Stewart SB, et al. In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia. Schizophr Res. 2009;113(2-3):322-331.
23. Bartzokis G, Lu PH, Amar CP, et al. Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory. Schizophr Res. 2011 Oct;132(1):35-41
24. Tishler TA, Bartzokis G, Lu PH, et al. Abnormal trajectory of intracortical myelination in schizophrenia implicates white matter in disease pathophysiology and the therapeutic mechanism of action of antipsychotics. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3(5):454-462.
25. Ren Y, Wang H, Xiao L. Improving myelin/oligodendrocyte-related dysfunction: a new mechanism of antipsychotics in the treatment of schizophrenia? Int J Neuropsychopharmacol. 2013;16(3):691-700.
26. Dietz AG, Goldman SA, Nedergaard M. Glial cells in schizophrenia: a unified hypothesis. Lancet Psychiatry. 2020;7(3):272-281.
27. Chen AT, Nasrallah HA. Neuroprotective effects of the second generation antipsychotics. Schizophr Res. 2019;208:1-7
28. Sagarwala R, Nasrallah HA. (In press.) The effect of antipsychotic medications on white matter integrity in first-episode drug naïve patients with psychosis. Asian Journal of Psychiatry.
29. Nasrallah HA. Let’s tear down the silos and reunify psychiatry and neurology. Current Psychiatry. 2013;12(8):9-10.

Psychiatry is Neurology: White matter pathology permeates psychiatric disorders

References

Pages

Recommended Reading