Dr. Junewicz is a PGY-4 psychiatry resident, and Dr. Capasso is Clinical Assistant Professor, Department of Psychiatry, New York University, New York, New York.
Disclosures The authors report no financial relationships with any manufacturer whose products are mentioned in this article or with manufacturers of competing products.
Patients with Creutzfeldt-Jakob disease (CJD) may present to psychiatric settings, particularly to a psychiatric emergency room. Consider CJD as a possible etiology in patients with rapidly progressive dementia, depression, and psychosis. CJD is invariably fatal and there is no effective disease-modifying treatment. Supportive therapies are the mainstay of care.