Brought to you by the Society of Gynecologic Surgeons. In this video, the authors highlight key surgical principles of vaginal cuff dehiscence repair. Vaginal cuff dehiscence is described as a full thickness separation of the vaginal cuff following hysterectomy. It can occur in up to 4.1% of cases. When managing vaginal cuff dehiscence, the surgeon should administer broad-spectrum antibiotic coverage, remove debris from the surgical site, inspect small bowel loops, manage bowel evisceration if present, freshen the proximal vaginal cuff edges, and reapproximate the vaginal cuff with delayed absorbable suture without tension.