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Gonadotropin Dose and Live Birth Rate

Are higher doses of FSH in order?

Publish date:: August 31, 2015

Live birth rate significantly decreased with increasing FSH dose, regardless of the number of oocytes retrieved in a study of 658,519 fresh autologous cycles of in vitro fertilization (IVF). Researchers determined:

• The statistically significant decrease in live birth rate with increasing FSH dose remained in patients with good prognosis, and regardless of female age; except for women aged ≥35 years with 1-5 oocytes retrieved.

• Analysis suggests that physicians may wish to avoid a high dose of FSH.

Citation: Baker VL, Brown MB, Luke B, Smith GW, Ireland JJ. Gonadotropin dose is negatively correlated with live birth rate: analysis of more than 650,000 assisted reproductive technology cycles. Fertility and Sterility. [Published online ahead of print August 18, 2015]. doi:10.1016/j.fertnstert.2015.07.1151.

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