Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions
Decline in Prevalence of HPV Evaluated
J Infect Dis; ePub 2018 Jul 16; Feiring, et al
Among a largely human papillomavirus (HPV)-naïve study population, a substantial reduction in vaccine- and non-vaccine types was observed in vaccinated and unvaccinated girls following introduction of the HPV vaccination. 3 birth cohorts of girls aged 17 years, 2 non-vaccine (born 1994/1995), and 1 vaccine-eligible cohort (born 1997) were invited to deliver urine samples. The samples were analyzed for 37 HPV genotypes. HPV was compared between birth cohorts, and between vaccinated and unvaccinated girls within and across birth cohorts after linkage to the Norwegian Immunisation Registry. Researchers found:
- In total, 17,749 urine samples were analyzed.
- Vaccine types were reduced by 54% in unvaccinated and 90% in vaccinated girls.
- Significant reduction was also observed for several non-vaccine types.
- Indication of cross-protection in both vaccinated and unvaccinated girls was also observed.
Feiring B, Laake I, Christiansen IK, et al. Substantial decline in prevalence of vaccine-type and non-vaccine type HPC in vaccinated and unvaccinated girls 5 years after implementing HPV vaccine in Norway. [Published online ahead of print July 16, 2018]. J Infect Dis. doi:10.1093/infdis/jiy432.
This Week's Must Reads
Must Reads in Vaccines
Vaccination for Prevention of Herpes Zoster, Ann Intern Med; ePub 2019 Feb 19; Prosser, et al
ACIP Updates Adult Immunization Schedule, Ann Intern Med; 2019 Feb 5; Kim, Hunter, et al
Influenza Vaccination Safety During Hospitalization, Mayo Clin Proc; ePub 2019 Jan 8; Tartof, et al
Acellular Pertussis Vaccine Is Safe & Effective, JAMA Pediatr; 2018 Nov; Wood, Nolan, et al
Influenza and Pertussis Vaccination in Pregnancy, Vaccine; ePub 2018 Nov 3; Wilcox, Bottrell, et al
This study of Norwegian girls showed that the HPV (four valent) vaccine was effective in decreasing the prevalence of HPV in the population that was vaccinated. This reinforces recommendations that we have in place. It was also great to see that this immunization program decreased HPV in the non-vaccinated population of studied girls. We do rely upon herd immunity for the success for most of our immunization programs for those who do not or cannot get vaccinated. Hopefully, having a vaccine that can decrease HPV infections will ultimately lead to less HPV-related malignancies in the future. We currently have about 27,000 cases each year. —John Russell, MD