Guerreiro R, Ross OA, Kun-Rodrigues C, et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. Lancet Neurol. 2018;17(1):64-74.
Preterm Newborns Have Altered Cerebral Perfusion
Altered regional cortical blood flow (CBF) in infants born very preterm at term-equivalent age may reflect early brain dysmaturation despite the absence of cerebral cortical injury, according to a study published online ahead of print November 30, 2017 in the Journal of Pediatrics. In this prospective, cross-sectional study, researchers used noninvasive 3T arterial spin labeling MRI to quantify regional CBF in the cerebral cortex of 202 infants, 98 of whom were born preterm. Analyses were performed controlling for sex, gestational age, and age at MRI. Infants born preterm had greater global CBF and greater absolute regional CBF in all brain regions except the insula. Relative CBF in the insula, anterior cingulate cortex, and auditory cortex were decreased significantly in infants born preterm, compared with infants born at full term.
Bouyssi-Kobar M, Murnick J, Brossard-Racine M, et al. Altered cerebral perfusion in infants born preterm compared with infants born full term. J Pediatr. 2017 Nov 30 [Epub ahead of print].
—Kimberly Williams