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Can Estrogen Exposure Inhibit PNET Growth?
Clin Endocrinol; ePub 2017 Apr 6; Qiu, Christakis, et al
Estrogen exposure appeared to inhibit pancreatic neuroendocrine tumor (PNET) growth in women with multiple endocrine neoplasia type 1, according to a retrospective chart review involving 141 individuals.
Investigators estimated estrogen exposure using measures of cumulative estrogen exposure time (CEET), parity, live birth pregnancies, and bilateral oophorectomy. Among the results:
- There was no significant link between CEET and time to PNET diagnosis.
- When analyzing the correlation between estrogen exposure and PNET type, size, numbers, distant metastasis, lymph node metastasis, lymphovascular invasion, American Joint Committee on Cancer stage, and overall survival, only CEET correlated with PNET size.
Qiu W, Christakis I, Stewart A, et al. Is estrogen exposure a protective factor for pancreatic neuroendocrine tumours in female patients with multiple endocrine neoplasia syndrome type 1? [Published online ahead of print April 6, 2017]. Clin Endocrinol. doi:10.1111/cen.13324.
This Week's Must Reads
Must Reads in Endocrine Cancer
T2D, Renal Cell Carcinoma Risk Linked in Women, Diabetes Care; ePub 2018 Apr 20; Graff, et al
Weight-Loss Efforts in Endometrial Ca Survivors, Cochrane; 2018 Feb 1; Kitson, Ryan, et al
Can Estrogen Exposure Inhibit PNET Growth?, Clin Endocrinol; ePub 2017 Apr 6; Qiu, Christakis, et al
Avoiding Surgery for Low-Risk Thyroid Cancer , Thyroid; ePub 2017 Jan 26; Griffin, Brito, et al
Frequency of PD-NETs in Patients with Endocrine Tumors, Clin Endocrinol; ePub 2016 Nov 17; Donegan, et al