History of hematopoietic cell transplantation (HCT) was linked with late morbidity and mortality in a study involving nearly 24,000 individuals.

Participants included 2-year HCT cancer survivors (n=1,792), non-HCT 2-year cancer survivors (n=5,455), as well as a cohort from the general population (n=16,340). Investigators looked at late outcomes and any subsequent cancers. Among the results:

• After median follow-up of ~7 years, HCT cancer survivors experienced 280 hospitalizations/1,000 person-years, vs 173 for non-HCT cancer survivors.
• They were also 10% more likely to experience all-cause mortality.
• HCT survivors were also 40% more likely to experience hospitalization or death with infection, and 40% more likely to have respiratory complications.
• They were also at risk for more digestive, skin, and musculoskeletal complications.
• Circulatory complications and second cancers were similar in both groups.
• Both contingents were more likely to have incidences with major organs vs the general population.