Parkinson's Disease
Literature Review
Blood NfL Accurately Differentiates Parkinson’s Disease From Atypical Parkinsonian Disorders
Quantification of blood neurofilament light chain (NfL) concentration effectively distinguishes Parkinson’s disease from atypical parkinsonian...
Conference Coverage
Is Closed-Loop DBS Ready for Clinical Application?
LAS VEGAS—Closed-loop deep brain stimulation (DBS) is effective in Tourette syndrome and Parkinson’s disease, according to an overview provided at...
From the Journals
Light therapy eases Parkinson’s-related sleep disturbances
A pilot randomized controlled study in Parkinson’s disease patients shows that light therapy shows promise for reducing daytime sleepiness and...
Conference Coverage
What Are the Best Treatments for Nonmotor Symptoms in Parkinson’s Disease?
PORTLAND, OR—Nonmotor symptoms are common in patients with Parkinson’s disease and they can substantially impact quality of life, according to an...
Conference Coverage
Patient Expectations May Be Potent Factor in DBS for Parkinson’s Disease
PORTLAND, OR—The discovery that a small amount of electricity delivered to the brain could help treat patients with Parkinson’s disease surprised...
Literature Review
Gene Mutation Linked to Early Onset of Parkinson’s Disease
A defect in a gene that produces dopamine in nigrostriatal cells appears to accelerate the onset of Parkinson’s disease, according to a study...
Conference Coverage
Treatment Advances in Parkinson’s Disease and Other Movement Disorders
LAS VEGAS—An oral extended-release agent composed of carbidopa–levodopa microbeads that was shown, in clinical studies, to improve symptoms in...
Conference Coverage
DBS and Optimal Therapy May Have Long-Term Benefit in Early Parkinson’s Disease
BALTIMORE—Deep brain stimulation (DBS) of the subthalamic nucleus, along with optimal drug therapy (ODT), produces clinically meaningful...
Literature Review
PINK1 Mutation Raises Risk of Early-Onset Parkinson’s Disease
The rare p.G411S mutation of PINK1 greatly increases the risk of early-onset Parkinson’s disease, even if present in only one allele,...
Conference Coverage
Safety and Efficacy of Five Years of Levodopa–Carbidopa Intestinal Gel Treatment
PORTLAND, OR—Most patients with advanced Parkinson’s disease who received levodopa–carbidopa intestinal gel in an open-label, continued-access-to-...
Conference Coverage
Amantadine Hydrochloride Reduces Levodopa-Induced Dyskinesia in Patients With Parkinson’s Disease
PORTLAND, OR—Amantadine hydrochloride extended-release capsules, compared with placebo, result in a statistically significant and clinically...