Low hippocampal dynamics in functional connectivity (dFC) is an important indicator for maintained memory performance in multiple sclerosis (MS), in addition to other hippocampal imaging measures, a recent study found. 38 MS patients and 29 healthy controls underwent neuropsychological tests to assess memory function. Imaging (1.5T) was obtained during performance of a memory task. Researchers assessed hippocampal volume, functional activation, and stationary FC (sFC) (ie, FC of the hippocampus with the rest of the brain averaged over the entire scan, using an atlas‐based approach). Dynamic FC of the hippocampus was calculated using a sliding window approach. They found:

• No group differences were found in hippocampal activation, sFC, and dFC.
• However, stepwise forward regression analyses in patients revealed that lower dFC of the left hippocampus (standardized β = −0.30) could explain an additional 7% of variance (53% in total) in verbal memory, in addition to female sex and larger left hippocampal volume.
• For visuospatial memory, lower dFC of the right hippocampus (standardized β = −0.38) could explain an additional 13% of variance (24% in total) in addition to higher sFC of the right hippocampus.