Resting state functional connectivity (RSFC) can be a valuable tool to monitor the motor and non-motor networks impacted in multiple sclerosis (MS) that relate to declines in motor impairment, according to a recent study. Furthermore, RSFC may identify critical nodes involved in a range of motor tasks, such as walking, that can be more sensitive to disruption by MS. 29 persons with MS underwent 3-T brain MRI and researchers computed RSFC among 68 gray matter regions of interest in the brain. Participants completed the Timed 25-foot Walk as a measure of walking performance. Researchers then examined associations using partial Pearson product-moment correlation analyses (r), controlling for age. They found that there were 8 cortical brain regions that were significantly associated with the T25FW, including the left parahippocampal gyrus and transverse temporal gyrus, and the right fusiform gyrus, inferior temporal gyrus, lingual gyrus, pericalcarine cortex, superior temporal gyrus, and transverse temporal gyrus.